Product Name :
CHK1-IN-4
Description:
CHK1-IN-4 (Compound 3) is a potent checkpoint kinase 1 (chk1) inhibitor, and potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 has anti-tumor activity.
CAS:
2120398-41-4
Molecular Weight:
444.29
Formula:
C18H18BrN7O2
Chemical Name:
5-({5-[2-(3-aminopropoxy)-4-bromo-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile
Smiles :
COC1=CC(Br)=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1
InChiKey:
LWOYEDQROLTYBT-UHFFFAOYSA-N
InChi :
InChI=1S/C18H18BrN7O2/c1-27-14-5-11(19)6-15(28-4-2-3-20)18(14)13-7-16(26-25-13)24-17-10-22-12(8-21)9-23-17/h5-7,9-10H,2-4,20H2,1H3,(H2,23,24,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CHK1-IN-4 (Compound 3) is a potent checkpoint kinase 1 (chk1) inhibitor, and potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 has anti-tumor activity.|Product information|CAS Number: 2120398-41-4|Molecular Weight: 444.29|Formula: C18H18BrN7O2|Chemical Name: 5-({5-[2-(3-aminopropoxy)-4-bromo-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile|Smiles: COC1=CC(Br)=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1|InChiKey: LWOYEDQROLTYBT-UHFFFAOYSA-N|InChi: InChI=1S/C18H18BrN7O2/c1-27-14-5-11(19)6-15(28-4-2-3-20)18(14)13-7-16(26-25-13)24-17-10-22-12(8-21)9-23-17/h5-7,9-10H,2-4,20H2,1H3,(H2,23,24,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{VV116} web|{VV116} RSV|{VV116} Biological Activity|{VV116} References|{VV116} custom synthesis|{VV116} Cancer} |Shelf Life: ≥12 months if stored properly.{{Pitavastatin} site|{Pitavastatin} Mitophagy|{Pitavastatin} Protocol|{Pitavastatin} In Vivo|{Pitavastatin} manufacturer|{Pitavastatin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33333164 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|CHK1-IN-4 (Compound 3) (40 mg/kg, IV, twice a week) alone enhances anti-tumor growth activity of CPT1 in the tumor model.|Products are for research use only. Not for human use.|
