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Nce.Abbreviations DS: double strand; LINE: long interspersed nucleotide element; LTR: long terminal repeats; MITE: miniature inverted-repeat transposable element; MULE: Mu-like element; ROM: read-only memory; RW: read-write; SINE: short interspersed nucleotide element; WGD: whole genome doubling. Competing interests The author declares that he has no competing interests. Received: 14 August 2009 Accepted: 25 January 2010 Published: 25 January 2010 References 1. McClintock B: Significance of responses of the genome to challenge. Science 1984, 226:792-801. 2. Darwin C: Origin of species London: John Russel 1859. 3. Lyell C: Principles of geology Edinburgh: John Murray 1830. 4. Wikipedia. http://en.wikipedia.org/wiki/Modern_evolutionary_synthesis. 5. Huxley J: Evolution: the modern synthesis London: Allen Unwin 1942. 6. Craig NL, Craigie R, Gellert M, Lambowitz AM: Mobile DNA II Washington, DC: American Society of Microbiology Press 2002. 7. McClintock B: A Correlation of ring-shaped chromosomes with variegation in Zea Mays. Proc Nat Acad Sci USA 1932, 18:677-681. 8. McClintock B: The Production of homozygous deficient tissues with mutant characteristics by means of the aberrant mitotic behavior of ring-shaped chromosomes. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28549975 Genetics 1938, 23:315-376. 9. McClintock B: The behavior in AKB-6548 web successive nuclear divisions of a chromosome broken at meiosis. Proc Nat Acad Sci USA 1939, 25:405-416. 10. McClintock B: The stability of broken ends of chromosomes in Zea Mays. Genetics 1941, 26:234-282. 11. McClintock B: The fusion of broken ends of chromosomes following nuclear fusion. Proc Nat Acad Sci USA 1942, 28:458-463.Shapiro Mobile DNA 2010, 1:4 http://www.mobilednajournal.com/content/1/1/Page 11 of12. McClintock B: Discovery and characterization of transposable elements: the collected papers of Barbara McClintock New York: Garland 1987. 13. Judson H: The eighth day of creation: makers of the revolution in biology New York: Simon Schuster 1979. 14. Crick F: On protein synthesis. Symp Soc Exp Biol 1958, 12:138-163. 15. Temin H, Mizutani S: RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 1970, 226:1211-1213. 16. Crick F: Central dogma of molecular biology. Nature 1970, 227:561-563. 17. Shapiro JA: Genome informatics: The role of DNA in cellular computations. Biological Theory 2006, 1:288-301. 18. Shapiro JA: Revisiting the central dogma in the 21st Century. Ann NY Acad Sci 2009, 1178:6-28. 19. Kunkel B, Losick R, Stragier P: The Bacillus subtilis gene for the development transcription factor sigma K is generated by excision of a dispensable DNA element containing a sporulation recombinase gene. Genes Dev 1990, 4:525-535. 20. Barbour AG, Restrepo BI: Antigenic variation in vector-borne pathogens. Emerg Infect Dis 2000, 6:449-457. 21. Gellert M: V(D)J recombination: RAG proteins, repair factors, and regulation. Ann Rev Biochem 2002, 71:101-132. 22. Garnier O, Serrano V, Duharcourt S, Meyer E: RNA-mediated programming of developmental genome rearrangements in Paramecium tetraurelia. Mol Cell Biol 2004, 24:7370-7379. 23. Pabo C, Sauer RT, Sturtevant JM, Ptashne M: The lambda repressor contains two domains. Proc Nat Acad Sci USA 1979, 76:1608-1612. 24. Doolittle RF: The multiplicity of domains in proteins. Annu Rev Biochem 1995, 64:287-314. 25. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, et al: Initial sequencing and analysis of the human genome. Nature 2001, 409:860-921. 26.

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