E. FASEB J 18:1276278 96. Chen HL, Bai H, Xi MM, Liu R, Qin XJ, Liang X et al (2013) Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase-2 and inducible nitric oxide synthase expression. J Appl Toxicol 33:717 97. Siddiki H, Kojicic M, Li G, Yilmaz M, Thompson TB, Hubmayr RD et al (2010) Bedside quantification of dead-space fraction applying routine clinical information in patients with acute lung injury: secondary evaluation of two prospective trials. Crit Care 14:R98. Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA et al (2004) Reduction of nitric oxide synthase-2 expression by distamycin A improves survival from endotoxemia. J Immunol 173:4147153 99. Mehta S (2005) The effects of nitric oxide in acute lung injury. Vasc Pharmacol 43:39003 100. Filipczak PT, Senft AP, Seagrave JC, Weber W, Kuehl PJ, Fredenburgh LE et al (2015) NOS-2 inhibition in phosgene-induced acute lung injury. Toxicol Sci 146:8900 101. Torkunov PA, Shabanov PD (2009) Utilizing NO-synthase inhibitors derived from l-arginine for preventing acute experimental lung edema improvement in mice. Eksp Klin Farmakol 72:446 102. Zwart A, Woutersen RA (1988) Acute inhalation toxicity of 2′-O-Methyladenosine supplier chlorine in rats and mice: time-concentration-mortality relationships and effects on respiration. J Hazard Mater 19:19508 103. Jonasson S, Koch B, Bucht A (2013) Inhalation of chlorine causes long-standing lung inflammation and airway hyperresponsiveness in a murine model of chemical-induced lung injury. Toxicology 303:342 104. Leikauf GD, Pope-Varsalona H, Concel VJ, Liu P, Bein K, Berndt A (2012) Integrative assessment of chlorine-induced acute lung injury in mice. Am J Respir Cell Mol Biol two:23444 105. Leustik M, Doran S, Bracher A, Williams S, Squadrito GL, Schoeb TR et al (2008) Mitigation of chlorine-induced lung injury by low-molecularweight antioxidants. Am J Physiol Lung Cell Mol Physiol 295:73343 106. Borak J, Diller WF (2000) Phosgene exposure: mechanisms of injury and therapy methods. J Occup Environ Med 43:11019 107. Withers RMJ, Lees FP (1985) The assessment of major hazards: the lethal toxicity of chlorine, element 2: model of toxicity to man. J Hazard Mater 12:28302 108. Withers RMJ, Lees FP (1987) The assessment of major hazards: the lethal toxicity of chlorine, component three: crosschecks from gas warfare. J Hazard Mater 15:30142 109. Yadav AK, Doran SF, Samal AA, Sharma R, Vedagiri K et al (2011) Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite. Am J Physiol Lung Cell Mol Physiol 300:L362 369 110. Yadav AK, Bracher A, Doran SF, Leustik M, Squadrito GL, Postlethwait EM et al (2010) Mechanisms and modification of chlorine-induced lung injury in animals. Proc Am Thorac Soc 7:27883 111. Weill H, George R, Schwarz M, Ziskind M (1969) Late evaluation of pulmonary function following acute exposure to chlorine gas. Am Rev Respir Dis 99:37479 112. Berthiaume Y, Matthay MA (2007) Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159:35059 113. Underhill FP (1920) The lethal war gases, physiology and experimental treatment. Yale University Press, New Haven 114. Underhill FP (1919) The physiology and experimental remedy of poisoning with all the lethal war gases. Arch Int Med. 23: 75370 Cited in WHO, 1997, 1998 115. Ware LB, Matthay MA (2000) The acute Vitamin A1 Epigenetic Reader Domain respiratory distress syndrome. N Engl J Med 342:1334349 116. Glas GJ, van der Sluijs KF, Schultz MJ, Hofstra J-JH, van der Poll.
