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Y research. According to the HepG2 and HepG2-CYP3A4 inC. Schulz et al. / Inhibition of phase-1 biotransformation and cytostatic effects of diphenyleneiodoniumvitro model systems employed, the results show that DPI mediated inhibition of phase-1 biotransformation could be accomplished. DPI is often used as an inhibitor of CYP3A4 activity at concentrations as much as 50 nM without the need of inducing any morphological or toxic effects around the cells. At concentrations 50 nM, cytostatic effects on HepG2 or HepG2-3A4 are to be expected, to ensure that influences or interactions with activity determinations can not be excluded, which should be taken into account accordingly.Acknowledgments This function was funded by grants from the Ministerium fr Wirtschaft, Forschung und Kultur (MWFK, u state of Brandenburg, Germany) for the Fraunhofer Project Group “Pilzbasierte zellfreie SynthesePlattformen PZ-Syn” (project quantity 22-F241-03-FhG/005/001).
Journal ofFungiArticleWhole Genome Sequencing and Annotation of Naematelia aurantialba (Basidiomycota, Edible-Medicinal Fungi)Tao Sun 1 , Yixuan Zhang 1 , Hao Jiang 1 , Kai Yang 1 , Shiyu Wang 1 , Rui Wang 1 , Sha Li 1 , Peng Lei 1, , Hong Xu 1, , Yibin Qiu two and Dafeng SunState Essential Laboratory of Materials-Oriented Chemical Engineering, College of Meals Science and Light Sector, Nanjing Tech University, Nanjing 211816, China; [email protected] (T.S.); [email protected] (Y.Z.); [email protected] (H.J.); [email protected] (K.Y.); [email protected] (S.W.); [email protected] (R.W.); [email protected] (S.L.) College of Light Sector and Meals Engineering, Nanjing Forestry University, Nanjing 210037, China; [email protected] Kunming Edible Fungi Institute of All China Federation of Supply and Marketing and advertising Cooperatives, Kunming 650032, China; [email protected] Correspondence: [email protected] (P.L.); [email protected] (H.X.); Tel.: +86-187-6168-1790 (P.L.); Tel./Fax: +86-25-5813-9433 (H.X.)Citation: Sun, T.; Zhang, Y.; Jiang, H.; Yang, K.; Wang, S.; Wang, R.; Li, S.; Lei, P.; Xu, H.; Qiu, Y.; et al. Entire Genome Sequencing and Annotation of Naematelia aurantialba (Basidiomycota, Edible-Medicinal Fungi). J. Fungi 2022, eight, six. doi/10.3390/jof8010006 Academic Editors: Luc Ram ez and Antonio Pisabarro Received: 11 November 2021 Accepted: 21 HDAC2 Synonyms December 2021 Published: 22 December 2021 Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Abstract: Naematelia aurantialba is a uncommon edible fungus with both nutritional and medicinal values and specially rich in bioactive polysaccharides. On the other hand, resulting from the lack of genomic information, researches on the mining of active compounds, artificial breeding and cultivation, genetics, and molecular biology are limited. To facilitate the medicinal and meals applications of N. aurantialba, we sequenced and analyzed the entire genome of N. aurantialba for the very first time. The 21-Mb genome contained 15 contigs, plus a total of 5860 protein-coding genes have been predicted. The genome sequence shows that 296 genes are related to polysaccharide synthesis, such as 15 genes related to nucleosideactivated sugar synthesis and 11 genes related to glucan synthesis. The genome also consists of genes and gene clusters for the synthesis of other active substances, including terpenoids, unsaturated fatty acids, and bioactive proteins. Furthermore, it was also identified that N. aurantialba was additional closely associated with Naematelia encephala than to ALK4 medchemexpress Tremella fuciformis. In quick, this.
