The cognitive effects of vortioxetine in human. Authors McIntyre et al., 2016 (28) Design Meta-analysis of three RCTs Population Present MDD Aged 18 yr. MADRS 26 Remedy(variety of patients) Vortioxetine 50 mg/d vs. Duloxetine 60 mg/d vs. Placebo Cognitive assessment DSST Key benefits Vortioxetine placebo for DSST immediately after correcting for modify in depression severity Vortioxetine duloxetine for DSST following correcting for transform in depression severity Vortioxetine other antidepressants for DSSTRosenblat et al., 2015 (38)Meta-analysis of 17 RCTs2,Baune et al., 2018 (39)Network meta-analysis of 12 RCTsMDD (three, 738)Vortioxetine (728) Duloxetine (714) Paroxetine (23) Citalopram (84) Phenelzine (28) Nortryptiline (32) Sertraline (49) Placebo Vortioxetine (725) Duloxetine (707) Citalopram (84) Escitalopram (54) Fluoxetine (127) Sertraline (240) Phenelzine (28) Desipramine (9) Nortriptyline (102)DSST or combined speed TMT-B; RAVLT; StroopDSSTVortioxetine placebo for DSST Vortioxetine other antidepressants for DSSTCRT, selection reaction time; DSST, Digit Symbol Sign Test; MDD, significant depressive disorder; MADRS, Montgomery- berg Depression Rating Scale; PDQ, Perceived Deficit Questionnaire; RAVLT, Rey Auditory Verbal Finding out Test; SRT, uncomplicated reaction time; TMT-A or -B, Trails Making Test; UPSA-B, San Diego Performance-Based Skills Assessment.Frontiers in Psychiatry | www.frontiersin.orgNovember 2019 | Volume 10 | ArticleBennabi et al.Vortioxetine for Cognitive Enhancement in Depressionand object recognition memory, with no affecting scopolamineinduced impairments in interest. In this study, a modest and short-lived rise of hippocampal acetylcholine (ACh) levels was equally reported. Subchronic vortioxetine administration, however, neither reversed scopolamine-induced social recognition memory deficits, nor affected basal hippocampal ACh levels. In yet another study, the exact same group (23) demonstrated that either acute or subchronic vortioxetine administration attenuates phencyclidine (an N-methyl–aspartate [NMDA] receptor antagonist) nduced deficits in attentional set shifting functionality and that both ondansetron (a selective 5-HT3 receptor antagonist) and escitalopram (a 5-HT reuptake inhibitor) can mimic this effect.Cabiralizumab supplier Moreover, subchronic vortioxetine reverses phencyclidine-induced object recognition and OP impairments in mice.Epothilone D medchemexpress Additional lately, Felice and collaborators (24) reported that vortioxetine improves context discrimination in mice.PMID:23659187 Even so, contrary to a preceding hypothesis [cf. (17)], this improvement was observed through a neurogenesisindependent mechanism. To sum up, in animal research, vortioxetine appears to have beneficial effects on depression-related behavior and cognitive deficits which can be distinct from those of SSRIs and serotoninnorepinephrine reuptake inhibitors (15, 19, 41, 44, 45). Altogether, these preclinical information supply further evidence from the therapeutic prospective of vortioxetine within the management of depression disorders such as depression-induced cognitive impairments in humans. The outcomes from these experiments also suggest that various mechanisms may very well be in the origin on the procognitive properties of vortioxetine. Certainly, it has been shown that vortioxetine exerts, as well as direct effects on serotonin, indirect effects on several neurotransmitters like noradrenergic, histaminergic, cholinergic, GABAergic, and glutamatergic systems (demonstrated in both in vitro and in vivo research) (ten, 51, 52).
