Product Name :
SRS11-92
Description:
SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
CAS:
1467047-25-1
Molecular Weight:
352.47
Formula:
C22H28N2O2
Chemical Name:
ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate
Smiles :
CCOC(=O)C1=CC(NCC2C=CC=CC=2)=C(C=C1)NC1CCCCC1
InChiKey:
VHQAJFNLPQULSV-UHFFFAOYSA-N
InChi :
InChI=1S/C22H28N2O2/c1-2-26-22(25)18-13-14-20(24-19-11-7-4-8-12-19)21(15-18)23-16-17-9-5-3-6-10-17/h3,5-6,9-10,13-15,19,23-24H,2,4,7-8,11-12,16H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of ferroptosis. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.{{EACC} medchemexpress|{EACC} Autophagy|{EACC} Technical Information|{EACC} References|{EACC} supplier|{EACC} Autophagy} |Product information|CAS Number: 1467047-25-1|Molecular Weight: 352.{{EACC} web|{EACC} Autophagy|{EACC} Purity & Documentation|{EACC} Purity|{EACC} manufacturer|{EACC} Autophagy} 47|Formula: C22H28N2O2|Chemical Name: ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate|Smiles: CCOC(=O)C1=CC(NCC2C=CC=CC=2)=C(C=C1)NC1CCCCC1|InChiKey: VHQAJFNLPQULSV-UHFFFAOYSA-N|InChi: InChI=1S/C22H28N2O2/c1-2-26-22(25)18-13-14-20(24-19-11-7-4-8-12-19)21(15-18)23-16-17-9-5-3-6-10-17/h3,5-6,9-10,13-15,19,23-24H,2,4,7-8,11-12,16H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).PMID:24118276 DMSO: 70 mg/mL(198.59 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts.|Products are for research use only. Not for human use.|
