Product Name: E2F1 (phospho Thr433) antibody
Applications: WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Full Name: E2F transcription factor 1
Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
Synonyms: RBBP3 Antibody , E2F-1 Antibody , RBP3 Antibody , E2F transcription factor 1 Antibody , RBAP1 Antibody , E2F1 Antibody
Cellular Localization:
CAS NO: 189453-10-9
Product: Rivastigmine (tartrate)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Peptide sequence around phosphorylation site of Threonine 433 (D-L-T(p)-P-L) derived from Human E2F1.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Store at -20˚C/1 year
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: The antibody detects endogenous level of E2F1 only when phosphorylated at Threonine 433.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26136213?dopt=Abstract
