Product Name: FAK (phospho Tyr397) antibody
Applications: ICC/IF, WB
Predicted Target Size: 119 kDa (note) (3)
Positive Controls: HUVEC , HUVEC (5 ng/ml VEGF treatment for 10 min) , HepG2 (200 ng/ml EGF treatment for 30 min) , HeLa
Form Supplied: Liquid
Concentration: 0.88 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: protein tyrosine kinase 2
Background: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. [provided by RefSeq]
Synonyms:
Cellular Localization: Cell junction , focal adhesion , Cell membrane; Peripheral membrane protein; Cytoplasmic side
CAS NO: 211735-76-1
LY2603618
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human FAK (phospho Tyr397). The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22721776?dopt=Abstract
