Product Name: Factor VIII antibody [5025]
Applications: ELISA, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 5 mg/ml (Please refer to the vial label for the specific concentration)
Purification:
Full Name: coagulation factor VIII, procoagulant component
Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq]
Synonyms: AHF, DXS1253E, F8 protein, F8B, F8C, FVIII, HEMA
Cellular Localization:
CAS NO: 28845-86-5
GBT 440
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Immunogen:
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 50% Glycerol
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25373911?dopt=Abstract
