Product Name: Factor XIIIa antibody [N1N3]
Applications: ICC/IF, IHC-P, WB
Predicted Target Size: 83 kDa (note)
Positive Controls: H1299
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: coagulation factor XIII, A1 polypeptide
Background: This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq]
Synonyms: F13A antibody, F13A1 antibody, protein-glutamine gamma-glutamyltransferase A chain antibody, fibrinoligase antibody, TGase antibody, “FSF, A subunit antibody”, coagulation factor XIIIa antibody, transglutaminase A chain antibody, “fibrin stabilizing factor, A subunit antibody”, transglutaminase. plasma antibody, “bA525O21.1 (coagulation factor XIII, A1 polypeptide) antibody”, “coagulation factor XIII, A polypeptide antibody”, factor XIIIa antibody, coagulation factor XIII A chain antibody, “coagulation factor XIII, A1 polypeptide antibody”
Cellular Localization: Cytoplasm , Secreted
CAS NO: 586368-06-1
XCT790
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human Factor XIIIa. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23795291?dopt=Abstract
