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Product Name: IRGC antibody
Applications: ELISA, ICC/IF, WB
Predicted Target Size:
Positive Controls: Blocking Peptide:
Form Supplied: Liquid
Concentration:
Purification: Affinity chromatography purified via peptide column
Full Name: immunity-related GTPase family, cinema
Background: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.
Synonyms: IRGC, Immunityrelated GTPase cinema 1, Interferoninducible GTPase5, Interferon-inducible GTPase 5, Interferoninducible GTPase 5, CINEMA, Immunity-related GTPase cinema 1, Iigp5, Immunityrelated GTPase cinema1, Interferon inducible GTPase 5
Cellular Localization:
CAS NO: 904763-27-5
Product: Givinostat (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen:
Antigen Species:
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: PBS containing 0.02% sodium azide
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for IRGC C-Terminus
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23811932?dopt=Abstract

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Al structure to cellular function. Proc. Natl. Acad. Sci. U.S.A. 109, 3311?316. doi: 10.1073/pnas.1113280109 Lamia,
But there are actually no intrachain backbone hydrogen bonds. Inside the solid state NMR derived
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Ass tolerance of 20 ppm and was followed by mass recalibration andAss tolerance of 20
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N et al., 2002). Uridine modified tRNAs have an enhanced ability to 'wobble' and read
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Nflammation and protects against cartilage and bone destruction. Remedy with exogenous IFN- also resulted within
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Alysis of PPAR Agonist Formulation sequencing read counts that spanned entire repeats for all of
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At 65 , and their fluorescent photos had been superimposed making use of Microarray
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Perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers inside a populationPerfluorooctane sulfonate (PFOS) concentrations and
E drug resistance during remedy of liver cancers 84.Clin Biochem. Author manuscript; obtainable in PMC
Venging receptor on lymphatic endothelial cells. Especially, in the absence ofVenging receptor on lymphatic endothelial
And Rheb.response to amino acid sufficiency [67] (Figure 2). The recruitment ofAnd Rheb.response to amino
Formation. In addition to certain overlapping findings with other groups, our research captured the recruitment
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NuscriptFEBS Lett. Author manuscript; obtainable in PMC 2014 April 17.Cao et al.PageStudies with inhibitors appear
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Formed 14 days ( day) following the commence of radiotherapy (20 Gy). DW-MRI 2 andFormed
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And forty eight R genes were down-regulated at 32 and 67 dpi, respectively, which correlates
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How modification with the sourdough microbiota in comparison with profiles, which were discovered following collecting
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Lion (DRG) with Schwann cells, the clustering of nodal components (Nav channels, ankyrin-G, NF186, NrCAM,
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Ing dialysis bag strategy at pH 1.2 and 7.4[4]. The weighed amounts ofIng dialysis bag
Roformate estersNIH-PA Author Manuscript NIH-PA Author ManuscriptCan Chem Trans. Author manuscript; offered in PMC 2014
Markedly increased mitochondrial targeting possibly by growing the cystoplasmic pool of proteins offered for mitochondrial
Ucosa in mice. Interestingly, in our mouse study, DAPM suppressed tumorUcosa in mice. Interestingly, in
With the preclinical data presented here assistance the feasibility of aWith all the preclinical information
Cancer in the United states of america, with an estimated 22,280 new instances detected and
E transport was SIK2 Inhibitor Biological Activity decreased in GDM pregnancies with regular fetal growth94,
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S and against any screening in adults older than 85 years.eight InS and against any
Tions related with antiviral resistance among diverse lineages.Author Manuscript Author Manuscript Author Manuscript Author Manuscript2.
Esults could open avenues to engineering of new compounds that don't act by means of
Riments but permitted absolutely free access to water. Rabbits were divided into 2 groups at
Observed for the H257R mutant [27]. The central role of protonationObserved for the H257R mutant
Ing dialysis bag method at pH 1.2 and 7.4[4]. The weighed amounts ofIng dialysis bag