Product Name: eIF3B antibody [N2C2], Internal
Applications: WB-Ag
Predicted Target Size: 92 kDa (note)
Positive Controls: Target recombinant protein
Form Supplied: Liquid
Concentration: 0.07 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: eukaryotic translation initiation factor 3, subunit B
Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Synonyms: EIF3-ETA antibody, EIF3-P110 antibody, EIF3-P116 antibody, EIF3S9 antibody, MGC104664 antibody, MGC131875 antibody, PRT1 antibody, EIF3B antibody, “eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa antibody”, prt1 homolog antibody, eukaryotic translation initiation factor 3 subunit 9 antibody, eIF-3-eta antibody, eIF3 p110 antibody, hPrt1 antibody, “eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD) antibody”, eIF3 p116 antibody, eukaryotic translation initiation factor 3 subunit B antibody, “eukaryotic translation initiation factor 3, subunit B antibody”
Cellular Localization: Cytoplasm
CAS NO: 1234480-84-2
Product: Alvespimycin (hydrochloride)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein encompassing a sequence within the center region of human eIF3B. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity:
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21593321?dopt=Abstract
