Product Name: DNase I antibody [N1C3]
Applications: ICC/IF, IHC-P, WB
Predicted Target Size: 31 kDa (note)
Positive Controls: Molt-4
Form Supplied: Liquid
Concentration: 0.93 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: deoxyribonuclease I
Background: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]
Synonyms: DKFZp686H0155 antibody, DNL1 antibody, DRNI antibody, FLJ38093 antibody, FLJ44902 antibody, DNASE1 antibody, Dornase alfa antibody, deoxyribonuclease-1 antibody, “DNase I, lysosomal antibody”, human urine deoxyribonuclease I antibody, deoxyribonuclease I antibody
Cellular Localization: Secreted , Nucleus envelope
CAS NO: 101975-10-4
Product: Poloxime
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Recombinant protein corresponding to human DNase I.
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/22238669?dopt=Abstract
