Product Name: E-Cadherin antibody
Applications: WB
Predicted Target Size: 135 (note)
Positive Controls:
Form Supplied: Liquid
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Full Name: cadherin 1, type 1, E-cadherin (epithelial)
Background: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
Synonyms: Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CDH1, epithelial cadherin, cadherin 1, E-cadherin (epithelial), calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, uvomorulin, cadherin-1, CAM 120/80, E-Cadherin, cadherin 1, type 1, E-cadherin (epithelial)
Cellular Localization:
CAS NO: 587871-26-9
Product: GW3965
Host: Rabbit
Clonality: Polyclonal
Isotype:
Immunogen: Peptide sequence around aa.864~868(E-W-G-N-R) derived from Human E-Cadherin.
Antigen Species: Human
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Storage Buffer: saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24347167?dopt=Abstract
