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Product Name: Endothelin B Receptor antibody [C3], C-term
Applications: IHC-P, WB
Predicted Target Size: 50 kDa (note) (3)
Positive Controls: A375 , Rat2
Form Supplied: Liquid
Concentration: 0.52 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified by antigen-affinity chromatography.
Full Name: endothelin receptor type B
Background: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq]
Synonyms: ABCDS antibody, ETB antibody, ETBR antibody, ETRB antibody, HSCR antibody, HSCR2 antibody, WS4A antibody, EDNRB antibody, endothelin receptor non-selective type antibody, endothelin B receptor antibody, endothelin receptor type B antibody
Cellular Localization: Cell membrane
CAS NO: 228559-41-9
Product: gamma-Secretase Modulators
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Endothelin B Receptor. The exact sequence is proprietary.
Antigen Species: Human
Species Reactivity: Human, Rat
Conjugation: Unconjugated
Storage Buffer: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage Instruction: Keep as concentrated solution. Aliquot and store at -20ÂșC or below. Avoid multiple freeze-thaw cycles.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity:
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27499083?dopt=Abstract

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