Product Name: FK506 antibody [FK1]
Applications: ELISA, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 2 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified IgM
Full Name:
Background: FK 506 antigen is a novel macrolide with similar but more potent immunosuppressant activity than cyclosporine. FK 506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK 506 TDM. The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml and depends on the patients liver function, the type of organ transplanted and the time after transplantation.
Synonyms:
Cellular Localization:
CAS NO: 1219810-16-8
Tebipenem
Host: Mouse
Clonality: Monoclonal
Isotype: IgM
Immunogen:
Antigen Species:
Species Reactivity:
Conjugation: Unconjugated
Storage Buffer: 50 mM Tris/HCl, 150 mM NaCl, pH 8.0 containing 0.1% of sodium azide as preservative.
Storage Instruction: Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: Recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=10-9M.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25482947?dopt=Abstract
