Product Name: FMRP (aa116-130) antibody, Internal
Applications: IHC, WB
Predicted Target Size:
Positive Controls:
Form Supplied: Liquid
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration)
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Full Name: fragile X mental retardation 1
Background: Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Synonyms: FRAXA, FMR1 (aa116130), MGC87458, fragile X mental retardation 1, FMR1, FMRP, fragile X mental retardation1, POF, POF1
Cellular Localization:
CAS NO: 73837-24-8
THZ1-R
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Immunogen: C-NPNKPATKDTFHKIK
Antigen Species: Human
Species Reactivity: Human
Conjugation: Unconjugated
Storage Buffer: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Storage Instruction: Aliquot and store at -20°C. Minimize freezing and thawing.
Notes: For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Specificity: This antibody is specific for FMRP (aa116-130).
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19226200?dopt=Abstract
